İdiyopatik Konjenital Kataraktı Olan Pediatrik Hastalarda Sistemik ve Oküler Oksidatif Stres Arasındaki İlişkinin İncelenmesi: Kesitsel Çalışma

Abstract

Objective: To investigate the systemic and ocular oxidant-antioxidant status of pediatric patients with idiopathic congenital cataracts. Material and Methods: This study investigated the serum and aqueous humor samples of 18 cases with idiopathic congenital cataract and the serum samples of 20 age-and sex-matched healthy cases. Total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), total thiol (T-SH), and thiobarbituric acid reactive substances (TBARS) levels in serum and aqueous humor samples were evaluated using spectrophotometric and spectrofluorometric methods. The weight, height, and body mass index parameters were recorded. Results: Study groups had statistically similar serum TAS, TOS, OSI, T-SH, and TBARS levels (p˃0.05). Statistically significant correlations between oxidant-antioxidant status in serum and aqueous humor were not detected in the patient group (p˃0.05). There was a statistically significant positive correlation was observed between the axial length and aqueous humor T-SH levels (r=0.651, p=0.042). Additionally, statistically significant positive correlation was observed between the age and serum TBARS levels in the patient group (r=0.422, p=0.008). Conclusion: In terms of oxidant-antioxidant status, this study did not find a correlation between serum and aqueous humor samples in pediatric patients with idiopathic congenital cataract and no difference in serum samples between study groups. This study suggests that oxidative stress may not be a part of idiopathic cataract development in the pediatric population.