Abstract
Objective: Diabetes is one of the biggest problems in the field of public health in the world. Vaccinium myrtillus L. extract, among the medicinal plants, has powerful antioxidant activity. For this aim, the possible effects of Vacillus myrtillus extract on serum paraoxonase (PON1), pancreatic enzyme levels, and lipid levels in experimental diabetic rats were investigated.
 Material and Method: A total of 32 male rats (Wistar albino) were used in this study and divided into four groups. Control (C), diabetic (D), Vaccinium myrtillus (VM), diabetes plus Vaccinium myrtillus (DVM) groups. In D and DVM groups, experimental diabetes was induced using a single dose of intraperitoneal 45 mg/kg streptozotocin. Vaccinium myrtillus extract was administered as 1.2 mg/kg/21 days by oral gavage in VM and DVM groups. At the end of the study; serum HbA1c, lipid parameters, amylase, lipase, and paraoxonase (PON1) enzymes were analyzed.
 Results: HbA1c was significantly reduced in diabetic groups treated with VM (VM and DVM). Cholesterol, LDL-C, and VLDL-C levels were significantly reduced after VM was administered to diabetic subjects, while other lipids were found to decrease insignificantly. Vaccinium myrtillus extract caused a slight decrease in pancreatic enzymes and a statistically significant increase in paraoxonase enzyme in the DVM group compared to group D.
 Conclusion: The obtained data support that Vaccinium myrtillus extract may play a potential protective role in preventing diabetes-associated complications.
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