Diyabet Oluşturulan Ratlarda Kurkuminin Bazı Plazma Sitokin Düzeyleri Üzerine Etkisi

Abstract

Objective: The aim of this study was to determine the effect of curcumin on some plasma cytokines and insulin levels in diabetes mellitus, which has negative effects on many acute and chronic systems in humans and animals. Material and Methods: In the study, thirty adult male Wistar albino rats with similar live weights were used. The subjects used in the study were divided into four groups including Control (K), Diabetes (D), Curcumin (C), and Diabetes+Curcumin (DC). At the end of the experiment, interleukin-6 (IL-6), IL-10, insulin, tumor necrosis factor alpha (TNF-α), and C-reactive protein (CRP) levels in the blood samples taken from the subjects in the groups were determined. Results: IL-6 level was determined to increase significantly in experimentally induced diabetic rats compared to the other three groups (p<0.05). The IL-6 level in the C group was found to be similar to that in the K group whereas it was observed that the IL-6 level was significantly lower in the DC group, in which C was supplemented for the experimentally induced diabetic rats, than in the D group, and approached to the levels obtained in the K and C groups (p<0.05). The CRP level was significantly higher in the D group compared to the other three groups whereas the insulin level was prominently lower (p<0.05). In this study, it was observed that there was a positive and strong relationship between IL-6 and TNF and CRP, and a moderately strong and negative relationship with insulin Conclusion: In conclusion, it was seen that curcumin application does not cause a negative impact on healthy rats and that it is beneficial in reducing the negative effects of diabetes in streptozotocin-induced diabetic rats.