Abstract
We present a new signal acquisition scheme termed D-evolution that improves NMR spectra for systems undergoing conformational exchange in the intermediate time scale. The new approach separates time scales of the conformational exchange and chemical shift evolution. This reduces line broadening by avoiding the situation of intermediate exchange. The chemical shift evolution is divided into a number of short intervals interlaced by Carr-Purcell-Meiboom-Gill (CPMG) blocks. We demonstrate this method for several test systems such as small molecules, cyclohexane, and acetonitrile as well as two globular proteins, azurin and protein-L.
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