Abstract
Our understanding of the pathophysiology and management of diverticular disease of the colon continues to evolve at a rapid pace. The study of the natural history of diverticulitis has led to the understanding that this disease may have fundamentally different mechanisms than those proposed in previous generations. Genetics, the microbiome, and environmental risk factors are increasingly recognized as major contributors to the evolution of diverticulosis and subsequent progression to complicated diverticulitis.
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