Abstract
A series of new substituted benzophenone derivatives was designed, synthesized and screened for their antifungal and antibacterial activities. The bioassays indicated that most of the synthesized compounds showed some antifungal activity against the tested phytopathogenic fungi, but lower antibacterial activities towards the five vibrios isolated from marine sources. The preliminary structure activity relationship (SAR) of the compounds was also discussed.
Highlights
Resistance and cross-resistance are found in the field when a class of agrochemicals has been used for a long time [1], exploring new agrochemical candidates with different modes of action is always meaningful
The carboxylic acid amide (CAA) fungicides, dimethomorph (II, Figure 1) and flumorph (III, Figure 1) [7,8] are derivatives of benzophenone and are common agrochemicals in the field in China nowadays. They have been widely used for years to control the diseases caused by Oomycete foliar plant pathogens (e.g., Phytophthora infestans (Mont.)
The biological activity evaluation indicated that the synthesized compounds were quite potent on most of the tested fungi, but much less effective on the five tested vibrios
Summary
Resistance and cross-resistance are found in the field when a class of agrochemicals has been used for a long time [1], exploring new agrochemical candidates with different modes of action is always meaningful. Metrafenone (I, Figure 1) is a novel benzophenone-derived fungicide [2] recently registered in several countries for control of powdery mildews in different crops [3,4] and eye spot in cereals [5]. It possess a different mode of action that might interfere with processes which are essential to establish and maintain polar action organization [6].
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