Abstract
Diversity of Globin Function: Enzymatic, Transport, Storage, and Sensing
Highlights
The availability of genomic information from the three kingdoms of life has altered substantially our view of the globin superfamily
The reactions with NO are common to all hemeproteins and likely represent one of the earliest and most important Hb functions
An additional possibility is that FHb exhibits 30 –50% identity to bacterial FHbs and is expressed in plays a role in the coordination of intracellular NO concentra- response to hypoxia (25)
Summary
The reactions with NO are common to all hemeproteins and likely represent one of the earliest and most important Hb functions. A role of RBCs in hypoxic vasodilation has been proposed in which S-nitrosylation of the -chain Cys residues is favored by the oxy-Hb conformation to form SNOHb, followed by NO transport as SNOHb to peripheral tissues, where release of NO is promoted by the deoxy-Hb conformation (8). The finding that SNOHb is formed during the reaction of deoxy-Hb with NO2Ϫ has led to the suggestion that S-nitrosylation of Cys at low oxygen concentrations is carried out by an intermediate in this reaction (9). Consistent with this idea, deoxy-Hb can act as an S-nitrosylated synthase under physiologically relevant conditions (10). The function of Ascaris Hb is thought to be NO-mediated control of O2 concentration, in contrast to FHbs, which use O2 to control NO concentration, and mammalian Hbs, which employ NO to regulate RBC oxygen delivery (19)
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