Diversity of Coordination Modes, Structures, and Properties of Chiral Metal–Organic Coordination Complexes of the Drug Voriconazole

Abstract

AbstractFive chiral metal–organic coordination compounds (CMOCCs), {[Cu4O(Lvcz)2Br4]·H2O}n (1), {[Cd(HLvcz)2(NO3)2]·0.25H2O}n (2), {[Cu2(HLvcz)2I2]·H2O}n (3), {[Ag(HLvcz)2]CF3SO3}n (4), and {[Co2(HLvcz)(bdc)2(dmf)2]·dmf·3H2O}n (5; HLvcz = voriconazole, bdc = terephthalic acid), have been successfully prepared and structurally characterized. The chiral drug ligand voriconazole exhibits diverse modes of coordination in the five complexes, resulting in the formation of various architectures and properties. Complex 1 is a tetranuclear cluster, complex 2 exhibits a 1D double‐strand chain structure in which hydrogen‐bonding interactions lead to a 3D supramolecular network, complex 3 is a 1D chain structure with two different types of rings based on the rhombic dimer Cu2I2, complex 4 is a 2D structure with 63 topology that contains four types of C–H···F hydrogen bonds, and complex 5 affords a 3D framework with sxa topology. Their properties, such as chirality, second‐order nonlinear optical (NLO) effects, ferroelectric behavior and dielectric anomalies, have been investigated in the solid state.