Diversity and joining segments of mouse immunoglobulin heavy chain genes are closely linked and in the same orientation: implications for the joining mechanism.

C Wood,S Tonegawa

doi:10.1073/pnas.80.10.3030

Diversity and joining segments of mouse immunoglobulin heavy chain genes are closely linked and in the same orientation: implications for the joining mechanism.

C Wood, S Tonegawa

Open Access

https://doi.org/10.1073/pnas.80.10.3030

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Journal: Proceedings of the National Academy of Sciences of the United States of America	Publication Date: May 1, 1983
Citations: 134

#Mouse Immunoglobulin Heavy Chain Genes #Gene Segments + Show 8 more

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Abstract

We have mapped 12 diversity (D) gene segments of mouse Ig heavy chains between 80 and 1 kilobases 5' to the four joining (JH) gene segments by molecular analysis of DNA clones isolated from recombinant phage and cosmid libraries. All identified D and JH segments are in the same 5'-3' orientation. The significance of these findings with respect to the joining mechanism for Ig gene segments is discussed.

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