Abstract
Diversification in<i>Salmonella</i>Typhimurium DT104
Highlights
To the Editor: Multidrug-resistant (MDR) Salmonella Typhimurium definitive phage type (DT) 104 with chromosomally encoded resistance to ampicillin, chloramphenicol, streptomycin/spectinomycin, sulfonamides, and tetracyclines (ACSSpSuT) was first identified and characterized in the United Kingdom in the early 1990s (1)
In the United Kingdom, outbreaks of MDR DT104 have been caused by new subclones with additional resistance to trimethoprim (Tm) (R-type ACSSpSu TTm) (7), by clones with decreased susceptibility to ciprofloxacin (CpL) (R-type ACSSpSuTCpL) (1), and by strains of R-type SSpSu
The absence of the serovarspecific plasmid (SSP) was reflected in the pulsed-field profile (PFP), which was identical to Xtm 1 but lacked a fragment of ≈90 kb that corresponds to the presence of the SSP (4)
Summary
To the Editor: Multidrug-resistant (MDR) Salmonella Typhimurium definitive phage type (DT) 104 with chromosomally encoded resistance to ampicillin, chloramphenicol, streptomycin/spectinomycin, sulfonamides, and tetracyclines (ACSSpSuT) was first identified and characterized in the United Kingdom in the early 1990s (1). In the United Kingdom, outbreaks of MDR DT104 have been caused by new subclones with additional resistance to trimethoprim (Tm) (R-type ACSSpSu TTm) (7), by clones with decreased susceptibility to ciprofloxacin (CpL) (R-type ACSSpSuTCpL) (1), and by strains of R-type SSpSu. In 2002, an outbreak of MDR DT104 ACSSpSuTTm with >200 cases was recognized (7). The outbreak strain was characterized by 3 plasmids of 6.8, 3.0, and 1.5 kb.
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