Abstract
Epithelial surfaces form critical barriers to the outside world and are continuously renewed by adult stem cells. Whereas epithelial stem cell dynamics in homeostasis are increasingly well studied, how stem cells are redirected from a tissue‐maintenance program to initiate tissue repair after injury remains incompletely understood. Our initial work focused on the interrelationship between stem cell populations in the gut, and in this talk I will present more recent studies examining the response of the intestinal epithelium to damage. Using a parasitic helminth that disrupts tissue integrity during its life cycle as a model, we found that tissue damage leads to re‐initiation of a developmental program, thus representing a fundamental and novel mechanism by which the intestinal crypt can remodel itself to sustain function after injury. I will also discuss our experiments using live imaging of adult intestinal organoids, which show that nascent daughter dispersal occurs when neighboring cells insert between them during cytokinesis. Our data suggest that the mechanics of progenitor cell division provide a driving force for cell mixing in elongated mammalian epithelia.Funding provided by NIH and CIRM.Support or Funding InformationFunding provided by NIH and CIRM.This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
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