Abstract
Geniposide is a well-known iridoid glycoside compound and is an essential component of a wide variety of traditional phytomedicines, for example, Gardenia jasminoides Elli (Zhizi in Chinese), Eucommia ulmoides Oliv. (Duzhong in Chinese), Rehmannia glutinosa Libosch. (Dihuang in Chinese), and Achyranthes bidentata Bl. (Niuxi in Chinese). It is also the main bioactive component of Gardeniae Fructus, the dried ripe fruit of Gardenia jasminoides Ellis. Increasing pharmacological evidence supports multiple medicinal properties of geniposide including neuroprotective, antidiabetic, hepatoprotective, anti-inflammatory, analgesic, antidepressant-like, cardioprotective, antioxidant, immune-regulatory, antithrombotic, and antitumoral effects. It has been proposed that geniposide may be a drug or lead compound for the prophylaxis and treatment of several diseases, such as Alzheimer's disease, Parkinson's disease, diabetes and diabetic complications, ischemia and reperfusion injury, and hepatic disorders. The aim of the present review is to give a comprehensive summary and analysis of the pharmacological properties of geniposide, supporting its use as a medicinal agent.
Highlights
Geniposide (C17H24O10; Figure 1), a well-known iridoid glycoside compound, is one of the main bioactive components of traditional Chinese medicine Gardeniae Fructus, the dried ripe fruit of Gardenia jasminoides Ellis (Zhizi in Chinese)
Studies have shown that geniposide displays a wide spectrum of in vitro and in vivo pharmacological effects, including neuroprotective, antidiabetic, hepatoprotective, anti-inflammatory, analgesic, antidepressant-like, cardioprotective, antioxidant, immune-regulatory, antithrombotic, and antitumoral effects, and these pharmacological effects lay the foundation for geniposide of being a potential therapeutic agent for the treatment of several diseases, such as Alzheimer's disease (AD), Parkinson’s disease (PD), diabetes and diabetic complications, ischemia and reperfusion injury, and hepatic disorders
Geniposide, the major iridoid glycoside of Gardeniae Fructus, has been isolated from nearly 40 species of plants and most of which are used as traditional phytomedicines
Summary
Geniposide (C17H24O10; Figure 1), a well-known iridoid glycoside compound, is one of the main bioactive components of traditional Chinese medicine Gardeniae Fructus, the dried ripe fruit of Gardenia jasminoides Ellis (Zhizi in Chinese). It has been isolated and identified in nearly 40 species of plants and most of which are medicinal herbs [1]. The aim of the present review is to give a comprehensive summary and analysis of the pharmacological properties of geniposide, supporting the potential uses of geniposide as a medicinal agent
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