Abstract
Classical model of prokaryotic translation initiation based on the central role of interactions between mRNA and 16S rRNA was proposed more than 30 years ago by Shine and Dalgarno. Since then, due to the rapid progress in genome sequencing and to novel technical approaches, basic researches have substantially enriched our knowledge on the problem. The present review focuses on the bioinformatic data as well as on experimental results obtained in vivo and in vitro, which show the diversity of molecular mechanisms for ribosome recruitment in prokaryotes.
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