Abstract
The health benefits of bovine colostrum have extensively been studied, including immune effects mediated by immunoglobulins, lactoferrin, and casein, as well as by certain growth factors. Some of these effects are not directly related to the absorption of proteins from the intestinal tract. The ingestion of BC can modulate the function of subsets of lymphocytes, macrophages, and dendritic cells and increase regulatory cytokines such as interleukin 10. In this review, we predominantly focused on evidence from human studies on benefits in health and disease. This review highlights that clear evidence of the prevention of infectious diseases in pre-term infants such as necrotizing enterocolitis, neonatal sepsis or prevention of cancer metastasis is lacking. This is clearly an area where translational science has to be strengthened, taking the considerable evidence from numerous ex vivo studies on cells and tissues and from animal interventions. The review focuses predominantly on human data.
Highlights
Bovine colostrum (BC), generally produced by the milk industry, is composed of a number of immune-active proteins such as immunoglobulins, lactoferrin and other antimicrobial peptides, and casein, and is marketed commercially with claims to promote general health and immune support
In this review. we present evidence of the diverse icmonhmdasuitpniDoreonevmesefonfaentfcsotttersbraetoitmnfhgoeBcrCeluecasharenaaldnloedfnprgoBoibntCeugns. tetIinieatfhltfheercirsetssroueovnfltiBienCiwtgs.inwboheewunpmnerefaisntoesrnsutinabesvjevicdataesrniicnocoeuhmosefaphltothehneaaeldntnihdvt edaroisnfseedaimmsdeu-islteiapslee numtruanceeuetffieccatlsso(fFBigCuarned1p).oIttenctainal, rheosuwlteinvgerb,ebneefidtisfifnicvualrtitoousbheecaeltrhtaainndodfisspeaesceifciocnedfifteiocntss of BC thaatftaerrethme eudseiaotfeBdCtheirtohuergohniimtsmowunneormasoaducolamtpioonneonrt tohfrmouulgtihplbeennuetfriaccieaulteicfafelsc(tFsigduuree t1o). other meItchcaann,ihsomwseovfera,cbteiodnif,fiscuuclthtoasbeincteerstatinaolfpsperemcifiecaebfifleictytsaonf dBCretghaetnaerreamtivedeieaftefedctthsr.ough immune modulation or through beneficial effects due to other mechanisms of action, such as intestinal permeability and regenerative effects
In a study on elderly, sedentary, non-smoking patients who met the inclusion criteria for immunogerontological studies and had low natural killer (NK) cell activity, a symbiotic mixture of Saccharomyces boulardii lysate in cranberry, colostrum-derived lactoferrin, Fragaria, and lactose was administered twice daily for 2 months and compared with an identically tasting fruit juice placebo
Summary
Bovine colostrum (BC), generally produced by the milk industry, is composed of a number of immune-active proteins such as immunoglobulins, lactoferrin and other antimicrobial peptides, and casein, and is marketed commercially with claims to promote general health and immune support. Significant changes in the bacterial composition of gut microbiota in pigs fed with multicomponent nutraceuticals were reported, with a higher number of probiotic strains such as Bifidobacterium, Streptococcus, and Faecalibacterium at the end of the experiment, compared to control group animals [2]. Such multi-component nutraceuticals should be further studied in human subjects. ImmMunaneyEofffethcetsefofefcCtsoolfocsotrlousmtruimn,Hesepaelctihally BC in healthy adults, have been explored in the context of sports nutrition These include immune effects and influences on intestinal perMmaenabyiloitfyt,haesehfafescbtseeonf creovloieswtreudmin, edspeteaciliabllyyDBaCviisnonheianltthhyisasderuiletss,[3h]a. Whether measuring serum cytokine levels is a robust indicator of subtle immune boosting effects is debatable [9]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
