Abstract
In our on-going study to investigate components with analgesic activity, eight new grayanane diterpenoids, epoxypieristoxins A–H (1–8), along with one known compound (9) were isolated from the roots of Pieris formosa. Their structures with absolute configurations were characterized by a series of spectroscopic methods and X-ray diffraction. Notably, compounds 1–5 represented the first example of natural grayanane diterpenoids possessed a 10,14-epoxy group. Whereas, compounds 6–7 were the first example of grayanane diterpenoid with a 7,10-epoxy group. Biological assays showed that compounds 1–3 and 5–8 displayed significant analgesic activity at a dose of 5.0 mg/kg (ip) compared to the vehicle tests (p < .05).
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