Abstract
Background of Study: Sickle cell anemic patients show diverse clinical symptoms with varied complications influenced by genetic, environmental and socioeconomic factors. Sickle cell anemia is prevalent in district Amravati, MS, India. In the present study, some symptomatic presentation of sickle cell anemic patients district Amravati, MS were studied in order to know pathophysiological complications going on in sickle cell anemia. In total, 67 sickle cell anemic patients were investigated. Information regarding some clinical symptoms was gathered from the patients and filled in the data sheets. It was observed that 77.77% patients frequently suffer from fever, 85.18% patients suffers from joint and chest pain, 81.48% experience recurrent tiredness, 85.18% experience shortness of breath, swelling of abdomen was found in 29.62% patients, 48.14% experience unusual headache. From the study of data sheet it was found that 29.62% sickle cell patients suffer from jaundice. In 51.85% patients, growth was delayed. Recurrent occurrence of pain episodes was observed in 55.55% patients. Thus sickle cell anemia in district Amravati shows variable clinical manifestations in variable percentage. Thus it is proposed to manage the disease properly as soon as it is detected.
Highlights
Sickle cell anemia is a genetic disorder, caused by mutation in the hemoglobin coding gene
The study population consisted of 67 randomized subjects with Sickle cell anemia from district Amravati, Maharashtra, India
It was observed that 77.77% patients suffer from fever, 85.18% patients suffers from joint and chest pain, 81.48% experience recurrent tiredness, 85.18% experience shortness of breath, swelling of abdomen was found in 29.62% patients, 48.14% patients experienced unusual headache
Summary
Sickle cell anemia is a genetic disorder, caused by mutation in the hemoglobin coding gene. Sickle cell anemia is caused due to substitution of valine for glutamic acid at sixth position of beta globin of hemoglobin [1,2]. This mutated and defective hemoglobin is less soluble and after deoxygenation undergo polymerization causing distortation of shape of (RBCs) Red Blood Cells [3]. Sickle cell anemic patients show diverse clinical symptoms with varied complications influenced by genetic, environmental and socioeconomic factors. Sickle cell anemia in district Amravati shows variable clinical manifestations in variable percentage. It is proposed to manage the disease properly as soon as it is detected
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