Abstract
IntroductionTo evaluate the frequency of divergent differentiations / variant morphology in urothelial carcinoma, and their association with muscle-invasive disease at diagnosis.MethodsAll consecutive cases of invasive urothelial carcinoma from a busy pathology laboratory were reviewed. Clinical and pathological data were recorded including data on divergent and variant morphologies and their percentage within the invasive component.ResultsAmong 91 cases, 46 (51%) showed some form of divergent/variant morphology. The most common divergent morphology was squamous which was present in 18/46 (39% of cases with some divergent or variant morphology) followed by micropapillary (28%), plasmacytoid (20%) and poorly differentiated (17%). Only squamous differentiation was associated with higher rate with muscularis propria invasion.ConclusionsAlthough common, squamous differentiation should be still recognized as a feature of aggressive disease.
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