Abstract
A new divergent synthesis of DAF-12 ligands, namely Δ 4- and Δ 7-dafachronic acid, is described starting from the natural bile acid hyodeoxycholic acid. Homologation of the side chain followed by stereoselective reduction of the Δ 24 olefinic linkage, 6α-dehydroxylation and C 3-oxidation affords dafachronic acids in good yields and high diastereoselectivity making this approach easily accessible and scalable.
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