Abstract
In this controlled clinical study, we determined the serum and follicular fluid concentrations of the biologically active fractions of magnesium (Mg) and calcium (Ca) in 39 women undergoing controlled ovarian stimulation (COH) for in vitro fertilization (IVF) embryo transfer (ET). Serum levels of ionized Ca (Ca<sup>2+</sup>) and ionized Mg (Mg<sup>2+</sup>) were measured during day 3 of the IVF cycle, on the day of ovum pickup and 12 days following ET. Follicular fluid levels were measured on the day of ovum pickup. Serum levels of Mg<sup>2+</sup> decreased and Ca<sup>2+</sup> levels increased during the IVF cycle. Mg levels were significantly higher in follicular fluid than in serum. Ca<sup>2+</sup> and Mg<sup>2+</sup> may play a role in the preovulatory follicle, a possibility that warrants further study.
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