Abstract
Diurnal variation in plasma concentrations of nelfinavir and ritonavir has previously been described. Plasma concentrations of 29 pharmaco-kinetic profiles with indinavir, amprenavir and saquinavir were evaluated, and a statistically significant median difference of 57.6% was found between morning and evening, with the morning C through being higher than the evening C through . Consequently, a change in dosing intervals might result in more balanced plasma protease inhibitor concentrations, thereby decreasing toxicity and the risk of virological failure.
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