Abstract
Intravenous diuretic treatment of volume overload in patients with heart failure is associated with no change or an increase in body weight at the time of hospital discharge in approximately 30% of patients entered in a large registry. This suggests that diuretic therapy itself or the endpoints for its discontinuation is ultimately ineffective in volume management. To investigate the mechanisms underlying this observation, changes in plasma volume were estimated using deidentified data obtained from 366 patients admitted to The Ohio State University Medical Center for management of heart failure and volume overload and who received intravenous diuretics.
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