Diuretic Effects of Aqueous Extract of Ficus exasperata Vahl. Leaves in Rat

Abstract

Ficus exasperata is widely used in african pharmacopoeia against hypertension and edema. The hypotensive effects of aqueous extract of F. exasperata leaves are reduced in the presence of atropine and methylene blue. The treatment of hypertension often requires the combination of antihypertensive drugs and diuretics substances. The aim of this study was to evaluate the effects of aqueous extract of F. exasperata leaves on urinary excretion in rat. Single doses of this extract (50 mg kg(-1) b.wt.) and furosemide (10 mg kg(-1) b.wt.) were administered to two groups of rats. A control group receives NaCl 9 per thousand. Urine excretion is collected, measured and sampled for 24 hours. At the end of the experiment, blood is sample. Urinary excretion volume induced by this plant extract was relatively high and greater than that induced by furosemide. Aqueous extract of F. exasperata leaves increased urinary excretion of electrolytes, creatinine and urea. However, creatinine and blood urea obtained are similar to those induced by furosemide. At the end of this work, it appears that aqueous extract of F. exasperata leaves induced a significant diuretic effect and electrolyte output which does not alter significantly the rate of electrolytes, creatinine and urea plasma.