Abstract
Prosopis farcta has been used traditionally for several diseases as cardiovascular, kidney, diabetes, bacterial infection and it has diuretic activity. This study was designed to evaluate the diuretic effects of P. farcta extract in comparison with spironolactone and hydrochlorothiazide in normal and hypertensive rats.Forty eight rats, were divided into Two groups. The First group was consist of Twelve normotensive rats, to represent the control group and normal treated group receiving 50 mg/Kg of P. farcta extract; Six rats in each group.
 The Second group involved 36 hypertensive rats, were divided into six subgroups, each of six rats. The First subgroups served as a positive control, the Second, Third and Fourth sub-groups were received 25, 50, 100 mg/Kg of P. farcta fruit extract respectively. The Fifth and Sixth subgroups were received 5 mg/kg spironolactone, and 25 mg/Kg thiazide orally for a week. P. farcta extract produced a significant increase in urine flow, Sodium excretion rate, eGFR and urinary creatinine level. In addition there were significant reduction in heart rate, and serum creatinine and blood urea.
 Conclusion: P. farcta fruit extract has mild diuretic activity in normal and hypertensive rats that resemble the potassium sparing diuretics.
 Keywords: Prosopis farcta, Diuretics, Thiazide, Spironolactone, Antihypertensive.
Highlights
Nowadays, several medications are either used as a single agent or in combination to manage cardiovascular among these medications are diuretics
P.f.f.e. :Prosopis farcta fruit extract SPL:spironolacton HCT: hydrochlorothiazide Values are expressed as mean ± SEM, Different letters indicate significant differences at P < 0.05
P.f.f.e.:Prosopis farcta fruit extract SPL :spirnolactone HCT: hydrochlorothiazide Values are expressed as mean ± SEM Different letters indicate significant differences at P < 0.05
Summary
Several medications are either used as a single agent or in combination to manage cardiovascular among these medications are diuretics. Diuretic frequently prescribed in a clinical setting to control blood pressure and fluid overload [1]. This type of medication is affordable, accessed, with minimum side effects, and can be used alone or with other antihypertensive drugs to have a blood pressure lowering, as a result avoiding resistant and complications [2]. Many plants have been used for diuretic purposes, such as Prosopis farcta fruit (P.f.f.), Matricaria Chamomilla, Mangifera indica, Mimosa pudica, Lipidium sativum, and Achyranthes aspera and Doradilla. In addition P. farcta had been studied comprehensively in cardiovascular diseases and have been successful in lowering blood pressure [5,6]. This study is designed to explore the potential diuretic effect of P. farcta fruit decoction in normotensive and hypertensive rat model.To this point, as far as the scientific research engine concern in English language there is not known study on diuretic properties of P. farcta fruit extract
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