Abstract
Diuretics are efficaciously used in management of various clinical emergencies like hypertension, heart failure, cirrhosis, hypercalciuria, hematuria and nephrotic syndrome. Cymbopogon jwarancusa is an aromatic perennial grass used in both traditional and Unani system of medicine to eradicate diseases like colds, seasonal fever, asthma, tuberculosis, rheumatic pain, back pain, toothache and nervous disorders. C. jwarancusa essential oils are used in perfumery, soap, detergents, medicines and pharmaceutical industry. Monoterpenes and sesquiterpenes constitute the highest composition in essential oil of C. jwarancusa. The present was designed to compare the diuretic activity of C. jwarancusa after single and multi-doses. Furosemide (20 mg/kg) was used as reference drug and 10% DMSO was used as vehicle. Diuretic activity was noticed by measuring urine volume and calculating diuretic and Lipchitz values. Maximum diuretic response was observed at 500 mg/kg of extract after both single and multi-dose administration. On basis of results it may be concluded that C. jwarancusa may be used as diuretic agent.
Highlights
Maintenance of homeostasis is very important for a normal healthy life, since existence of life becomes difficult if any change disturbs this balance
Diuretics are efficaciously used in management of various clinical emergencies like hypertension, heart failure, cirrhosis, hypercalciuria, hematuria and nephrotic syndrome
The present was designed to compare the diuretic activity of C. jwarancusa after single and multi-doses
Summary
Maintenance of homeostasis is very important for a normal healthy life, since existence of life becomes difficult if any change disturbs this balance Diuretics preserve this balance by maintain blood volume as well as concentration of excess ions in the body. Loop diuretics are most effective as causes excretion of 20% - 25% of sodium and water while thiazide diuretics are moderate in action causing excretion of 5% - 8% sodium whereas potassium sparing diuretics are least effective since excrete only 2% - 3% of sodium. C. jwarancusa is an aromatic perennial grass (Rusha grass, khavi grass) belonging to family Poaceaea, used in both traditional and Unani system of medicine for treatment of various ailment e.g. vomiting, fever, inflammatory condition, blood impurities and skin problems [6]. Current study is designed to explore the diuretic potential of C. jwarancusa leaves extract at different does after single and multiple doses
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