Abstract
Purpose: To evaluate the diuretic activity of Rubus idaeus L in experimental rats. Methods: Hot-water and methanol extract of three kinds of Rubus idaeus L. fruits were administered to experimental rats orally at a dose of 2 and 5 mg/kg. Hydrochlorothiazide (10 mg/kg) was used as positive control in study. The diuretic effect of the extracts was evaluated by measuring urine volume, sodium and potassium excretion in the urine. Results: Compared with the control group, significant increase in urine volume was observed from the experimental animal treated with wild raspberry methanol extract. In addition, we find that the methanol extract of wild raspberry fruits shows a potassium-conservation diuretic effect, which is a very interesting property in a phytodiuretic. Conclusion: Methanol extract of wild raspberry fruits have diuretic effect on experimental rats. This might be the first formal reports on diuretic effect of raspberry fruits, which can also, to some extent, explain the use of raspberry as a cure for renal diseases in Chinese traditional medical practice.
Highlights
Rubus idaeus L., is a plant belonging to the Rosaceae family, genus Rubus
The total urine volume of animals treated by raspberry methanol extract (RM) was high (2.32±0.12 ml/100 g BW) was statistically higher than the volume for the control group
The wild species collected from China showed significant diuretic effect in experimental rats, indicating that wild raspberry fruits might contain more diuretic active components than those cultivated fruits
Summary
Rubus idaeus L., is a plant belonging to the Rosaceae family, genus Rubus. The first two types were obtained from a local market, while the third (wild raspberry fruits) was collected from LiaoNing Province, China by local traditional medicine practitioners in 2008. They were identified and authenticated as Rubus ideaus L. by Professor Jincai Lu (College of Traditional Chinese Meteria Medica, ShenYang Pharmaceutical University, China). The rats (48) were fasted for 18 h with free access to drinking water, and orally administered 30 ml/kg of bicarbonate saline solution (containing 110mM NaCl and 30mM NaHCO3) Thirty minutes later, they were divided into 8 groups (n = 6) and the control group was given 10ml/kg of distilled water. When compared with control group, p-values less than 0.05 were considered statistically significant
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
