Abstract
AbstractLiquidambarine D (1), a new labdane‐type diterpenoid, and nineteen known compounds including five labdanes (2–6), eight abietanes (7–14), four pimaranes (16–19), and two nor‐diterpenoids (15, 20) were isolated from the resin of Liquidambar formosana Hance. The new compound was characterized by the combination of spectroscopic and computational methods. With the exception of 15‐hydroxydehydroabietic acid (13), all the known compounds were reported for the first time from the resins of Liquidambar species. All these isolates were evaluated for their inhibitory effects in RAW264.7 macrophage cells, revealing that compounds, acetylisocupressic acid (3), (13S)‐15‐acetoxylabd‐8(17)‐en‐19‐oic acid (6), abietic acid (7), dehydroabietic acid (11), abieta‐8,11,13,15‐tetraen‐18‐oic acid (12), and 4‐epi‐isopimaric acid (16) could suppress lipopolysaccharide‐induced iNOS expression in RAW 264.7 cells and disclosing their structure activity relationships.
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