Diterpenoids and triterpenoids with potential anti-inflammatory activity from the leaves of Aglaia odorata

Abstract

Chemical investigation of the leaves of the oriental medicinal plant Aglaia odorata resulted in the isolation of five compounds: two dolabellane diterpenoids, two dammarane triterpenoids and a protostane triterpenoid, along with twenty known compounds. Their structures were elucidated on the basis of extensive spectroscopic analysis and by comparison of their NMR spectroscopic data with those reported in the literature. The anti-inflammatory activities of all compounds were evaluated as inhibitory activities against lipopolysaccharide (LPS) induced nitric oxide (NO) production in RAW264.7 cell lines. Eleven compounds possessed potent nitric oxide inhibitory activity with IC50 values ranging from 2.1 to 14.2μM, these being better than that of the positive control, indomethacin (IC50=14.5μM). In addition, three compounds exhibited significant activity against PGE2 release with IC50 values of 2.6, 16.1 and 23.0μM.