Abstract
Three new jatrophane diterpenes (1–3), an unreported spectroscopic data jatrophane diterpenene (4), and nine known analogues (5–13) have been isolated from the whole plants of Euphorbia helioscopia. Their structures were established by detailed spectroscopic data analyses (IR, ESIMS, HR-ESIMS, and 1D and 2D NMR), and the structure of 1 was confirmed by X-ray crystallography. The diterpenes showed inhibitory activities on LPS-induced NO production in murine microglial BV-2 cells.
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