Abstract
Species of the brown algae of the genus Dictyota are rich sources of bioactive secondary metabolites with diverse structural features. Excellent progress has been made in the discovery of diterpenes possessing broad chemical defensive activities from this genus. Most of these diterpenes exhibit significant biological activities, such as antiviral, cytotoxic and chemical defensive activities. In the present review, we summarized diterpenes isolated from the brown algae of the genus.
Highlights
Marine brown algae of the genus Dictyota, belonging to the family Dictyotaceae, are mainly distributed in subtropical and tropical oceans [1]
Based on the revised biogenetic scheme widely cited, the diterpenes from Dictyota species can be divided into three groups (I–III), resulting from the first formal cyclization of the geranyl-geraniol precursor
A bioactive diterpene 137 was isolated from a Brazilian D. cervicornis [64]
Summary
Marine brown algae of the genus Dictyota, belonging to the family Dictyotaceae, are mainly distributed in subtropical and tropical oceans [1]. Hundreds of bioactive natural products, including terpenes, phenols [3], sterols [4], fatty acids [5], and polysaccharides [6], have been isolated from marine brown algae of the genus Dictyota. Diterpenes are a large class of structurally diverse natural products which are widely found in marine organisms, including Dictyota species [7]. Diterpenes from members of this genus usually exhibit potent cytotoxic or antiviral activities [12,13]. We systematically summarize the structures and bioactivities of diterpenes derived from members of the genus Dictyota, with more than 80 references cited. It has been reported that many of these diterpenes possess several interesting bioactivities, including cytotoxic and antiviral activities
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