Abstract
Abstract Two new alkaloids tentatively named as “denudatine” and “denudatidine” have been isolated in pure form from an indigenous crude drug “Judwar” which has been provisionally identified as the roots of Delphinium denudatum Wall. (Fam. Ranunculaceae). The purity of these alkaloids has been checked by paper chromatographic analysis and they have been characterised. Denudatine is the major alkaloid and has been isolated in pure form in a yield of 0.05 per cent. On the basis of microanalysis for the elements of the base, m.p. 248–249° and its derivatives; the determination of the active hydrogen, =N–Me, ≡C–Me and infra-red and ultra-violet absorption spectra, denudatine has been tentatively classified as a diterpene alkaloid of atisine group. Pharmacological actions of denudatine have been investigated. The normal rhythmic contractions of isolated rabbit duodenal strip are inhibited. The isolated guinea-pig uterine strip is stimulated by the base solution. It decreases the tone and inhibits the peristaltic movements of the intestine but does not show any effect on the blood pressure and respiration of the anaesthetised dog. It is non-toxic and lacks curariform activity. Denudatidine, m.p. 273° (yield, 0.003 per cent) has not been studied further.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
