Disulfiram Induced Reversible Hypertension: A Prospective Case Study and Brief Review

Abstract

Disulfiram (DSF) is one of the recommended aids in the management of alcohol dependence. Hypertension may be a clinically significant, dose-dependent, and usually reversible adverse event of DSF therapy. We report 6 month prospective study of normotensive case of comorbid alcohol and tobacco dependence that developed reversible stage-II hypertension within 2-4 weeks of DSF therapy. We suggest that regular monitoring of blood pressure at least fortnightly for 1st 3 months, followed by monthly for next 3 months, and later once in 3 months, may possibly detect “silent” adverse event of DSF – hypertension.