Abstract
Hald and Jacobsen (1948) introduced disulfiram as an adjunct in the treatment of alcoholism. Its usefulness has, however, been limited by the ease with which patients may discontinue medication and resume drinking. A preparation of disulfiram suitable for implantation was developed some years ago, and though its use has been mainly confined to the continent of Europe, several case reports have been published in this country (Kellam et al., 1968; Kellam, 1969). Madden and Malcolm (1972) suggest, from a follow-up study of 47 alcoholics, that implantation is followed by a period of sobriety of about six months, but they have made no comparison with a control group of patients.
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