Disulfidptosis-Related LncRNA Signatures for Prognostic Prediction in Kidney Renal Clear Cell Carcinoma

Abstract

Disulfidptosis is a prevalent apoptotic mechanism, intrinsically linked to cancer prognosis. However, the specific involvement of disulfidptosis-related long noncoding RNA (DRLncRNAs) in kidney renal clear cell carcinoma (KIRC) remains incompletely understood. This study aims to elucidate the potential prognostic significance of DRLncRNAs in KIRC. Expression profiles and clinical data of KIRC patients were retrieved from The Cancer Genome Atlas database to discern differentially expressed DRLncRNAs correlated with overall survival (OS). Employing Cox regression analysis, a LncRNA risk model was formulated and subsequently assessed for its prognostic efficacy.We have conducted a comprehensive examination of the associations between LncRNA features and their impact on cellular functions, pathways, immune status, and immune checkpoints. Six signatures, namely FAM83C.AS1, AC136475.2, AC121338.2, AC026401.3, AC254562.3, and AC000050.2, were established to evaluate OS in the context of KIRC in this study. Survival analysis and receiver operating characteristic curves demonstrated the strong predictive performance of the associated signature. The nomogram exhibited accurate prognostic predictions for overall patient survival, offering substantial clinical utility. Gene set enrichment analysis revealed that risk signals were enriched in various immune-related pathways. Furthermore, the risk features exhibited significant correlations with immune cells, immune function, immune cell infiltration, and immune checkpoints. This study has unveiled, for the first time, 6 disulfidptosis-related LncRNA signatures, laying a solid foundation for enhanced and precise prognostic predictions in KIRC.