Abstract
L-Glutamine and glutamic acid were incorporated in a tetrahydro-2H-1,3,5-thiadiazine-2-thione (THTT) skeleton contg. different alkyl, cycloalkyl and aralkyl groups at N3 of the ring system. These THTT derivs. revealed high lipophilicity compared with L-glutamine and glutamic acid. The degrdn. kinetics were studied -in vitro- using aq. buffer solns. of pH values: 1.2, 6.0, 7.4, 7.8 and 9.0 at 37°. From the pH profile, the degrdn. was accounted for, in terms of specific base-catalyzed reactions. All of the compds. however, showed higher acid-stability.
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