Abstract
Background The normal pattern of left ventricular (LV) inflow and ejection of affects the efficiency of cardiac pumping performance. Altered inflow direction due to a corrected atrioventricular septal defect (AVSD) may disturb this pattern leading to decreased efficiency. We aimed to quantitatively describe the LV blood flow pattern using 4-dimensional velocity-encoded cardiac magnetic resonance imaging (4DFlow MRI) and particle tracing in healthy volunteers and corrected AVSD patients.
Highlights
The normal pattern of left ventricular (LV) inflow and ejection of affects the efficiency of cardiac pumping performance
At end-diastole the LV was evenly filled with particles and subsequently tracked by backward and forward particle tracing to analyze the LV 4-componental flow as introduced by Eriksson [JCMR, 2010] discriminating 1. direct flow entering and leaving the LV within one cycle, 2. retained flow entering during diastole but remaining in LV during systole, 3. delayed ejected flow already in LV before diastole and leaves LV during systole 4. residual volume
Patients showed a smaller percentage of direct flow compared to volunteers (30±9% versus 44±11%, p
Summary
The normal pattern of left ventricular (LV) inflow and ejection of affects the efficiency of cardiac pumping performance. Altered inflow direction due to a corrected atrioventricular septal defect (AVSD) may disturb this pattern leading to decreased efficiency. We aimed to quantitatively describe the LV blood flow pattern using 4-dimensional velocity-encoded cardiac magnetic resonance imaging (4DFlow MRI) and particle tracing in healthy volunteers and corrected AVSD patients
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