Abstract
Abnormity in brain regional function and inter-regional cooperation have been linked with the dysfunction during cognitive and emotional processing in bipolar disorder (BD) patients. Recent evidences have suggested that brain function is not static but temporal dynamic. In present study, we aimed to characterize the temporal dynamics of regional function and inter-regional cooperation in BD and its relationship with executive dysfunction, an important deficit in BD. Resting-state functional MRI was performed in patients with bipolar I disorder (BDI) (n = 18) and healthy controls (HCs, n = 19). We first assessed local-function temporal variety with dynamic amplitude of low-frequency fluctuation (dALFF). Region with significant inter-groups difference in dALFF was chosen as a seed to calculate inter-regions connective temporal variety with dynamic functional connectivity (dFC). The executive function was measured by Verbal Fluency Test (VFT). The relationship between executive function and brain dynamics were examined. Compared with HC, the BDI group showed decreased dALFF (less temporal variability) in the posterior cingulate cortex (PCC) and decreased dFC between PCC and medial prefrontal cortex (mPFC). The PCC-mPFC dFC was positively associated with VFT in BDI patients, but not in HC. These findings implicated the reduced temporal variability in local region and inter-regions cooperation in BDI, which may be a neural substrate of executive-function deficit in BDI.
Highlights
Bipolar disorder (BD) is a common psychiatric disorder with remarkable mood instability, characterized by recurrent episodes of mania, hypomania, depression, and euthymic mood states [1]
We mainly aimed at exploring the temporal dynamics of resting-state local activity and functional connectivity in patients with bipolar I disorder (BDI), as well as its relationship with clinical symptoms and executive function
Our results suggested that patients with BDI showed decreased dynamic amplitude of low-frequency fluctuation (dALFF)
Summary
Bipolar disorder (BD) is a common psychiatric disorder with remarkable mood instability, characterized by recurrent episodes of mania, hypomania, depression, and euthymic mood states [1]. Neurocognitive dysfunction is another core feature of BD, which present in affective episodes, and in euthymic periods. The neurocognitive dysfunctions involve multiple cognitive processes, including memory, attention, reward and executive function [2,3,4,5]. Executive dysfunction is an important domain in BD, even considered as the specific deficit in BD. Executive dysfunction in BD are associated with poor social function [6, 7], delayed recovery [8] and higher readmission rate [9]. The neural substrates of the executive dysfunction are still unclear for
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