Abstract
Disturbance of the transmembrane phosphatidylserine asymmetry in hepatocytes as an apoptosis marker under the action of xenobiotics on rats
Highlights
The use of constantly growing range of cosmetics and detergents, washing powders and modern building materials in the everyday life of Ukrainians determines the increasing role of surfactants in all fields of human activities [1,2,3]
Cell death is most frequently mediated by a common molecular pathway termed apoptosis
Another form of cell death is called necrosis and occurs when cells are subjected to excessive stresses: lack of oxygen, heat, etc
Summary
The use of constantly growing range of cosmetics and detergents, washing powders and modern building materials in the everyday life of Ukrainians determines the increasing role of surfactants in all fields of human activities [1,2,3]. Based on the results of numerous experimental studies on warm-blooded animals, it has been established that surfactants modulate radiomimetic effects in biological objects and stimulate the development of free radical pathology, which in turn leads to the development of membrane pathology [7,8,9]. The rate and modes of hepatocyte cell death under the influence of them has not been yet studied. The aim of our study was to estimate phosphatidylserine distribution in the phospholipid bilayer of hepatocytes and cell death modes of hepatcytes under the influence of surfactants: ethylene glycol (EG), polyethylene glycol 400 (PEG-400) and polypropylene glycol (PPG) at a dose of 1/10 DL50
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