Abstract
Cytomegalovirus (CMV) infection is one of the causes of congenital neurological disorders and the virus itself is the most common viral agent causing an imbalance in the production of placenta progesterone and its neuroactive metabolites – allopregnenolone and 5α-dihydroprogesterone. The aim was to evaluate the concentration of progesterone and its metabolites – 5α-dihydroprogesterone and allopregnenolone – in placenta during exacerbation of CMV infection in the first trimester of pregnancy, and the impact of these disturbances on the development of neurological disorders in children. We examined 30 pregnant women with exacerbation of CMV infection in the first trimester of pregnancy and 30 pregnant women with latent disease; and later their newborns. The enzyme immunoassay was used to determine concentration of progesterone in placenta; the histochemical method – to determine 5α-dihydroprogesterone and allopregnenolone. Newborns underwent neurosonography studies. Exacerbation of CMV infection in the first trimester of pregnancy decreased progesterone in placenta by 1.3 times, 5α-dihydroprogesterone – by 1.73 times and allopregnenolone – by 2 times. Ultrasound examination of the brain showed ventriculomegaly, periventricular ischemia, and pseudocysts in newborns up to one year from mothers with exacerbation of CMV during pregnancy. Later, minimal brain dysfunctions were manifested by motor disorders, increased general, vegetative excitability, and a tendency to digestive and sleep disorders. The data obtained indicate that the exacerbation of CMV infection in the first trimester of pregnancy is interrelated with a decrease in the concentration of progesterone and its metabolites (5α-dihydroprogesterone, allopregnenolone) in the placenta and development of neurological dysfunction in newborns.
Highlights
Cytomegalovirus (CMV) infection is one of the causes of congenital neurological disorders and the virus itself is the most common viral agent causing an imbalance in the production of placenta progesterone and its neuroactive metabolites – allopregnenolone and 5α-dihydroprogesterone
The aim was to evaluate the concentration of progesterone and its metabolites – 5α-dihydroprogesterone and allopregnenolone – in placenta during exacerbation of CMV infection in the first trimester of pregnancy, and the impact of these disturbances on the development of neurological disorders in children
We examined 30 pregnant women with exacerbation of CMV infection in the first trimester of pregnancy and 30 pregnant women with latent disease; and later their newborns
Summary
Цитомегаловирусная (ЦМВ) инфекция является одной из причин врождённых неврологических расстройств, а сам вирус – наиболее распространённым вирусным агентом, вызывающим дисбаланс в продукции плацентой прогестерона и его нейроактивных метаболитов – аллопрегненолона и 5α-дигидропрогестерона. Цель исследования – оценить содержание прогестерона и его производных – 5α-дигидропрогестерона и аллопрегненолона – в плаценте с целью выявления причинно-следственной взаимосвязи и определения предикторов неврологических расстройств у детей при обострении ЦМВ-инфекции в первом триместре беременности. Обострение ЦМВ-инфекции в первом триместре беременности приводило к уменьшению содержания в плаценте прогестерона в 1,3 раза, 5α-дигидропрогестерона – в 1,73 раза и аллопрегненолона – в 2 раза. Полученные данные свидетельствуют о том, что обострение ЦМВинфекции в первом триместре беременности взаимосвязано с дефицитом прогестерона и его метаболитов (5α-дигидропрогестерон, аллопрегненолон) в плаценте и развитием неврологических дисфункций у новорождённых детей. The data obtained indicate that the exacerbation of CMV infection in the first trimester of pregnancy is interrelated with a decrease in the concentration of progesterone and its metabolites (5α-dihydroprogesterone, allopregnenolone) in the placenta and development of neurological dysfunction in newborns. Поэтому возникает необходимость раскрытия причин снижения уровня нейростероидов во время осложнённой ЦМВинфекцией беременности
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More From: Acta Biomedica Scientifica (East Siberian Biomedical Journal)
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