Abstract
Iseki et al. [1] reported severe spongy changes and ubiquitin, α-synuclein-positive spheroids in the central amygdaloid nucleus (AMN) in all examined cases of dementia with Lewy bodies (DLB) and in the cortical and accessory basal AMN in five of nine DLB brains in which lesions were correlated with the degree of neuronal loss in substantia nigra (SN). In Parkinson's disease (PD), there were mild spongy changes with severe gliosis in the central AMN despite severe neuronal loss in SN, while in Alzheimer's disease (AD), the central AMN showed neither spongy changes nor gliosis. The lesions in central AMN were suggested to originate from the degeneration of terminal or distal axons of Lewy body (LB)-bearing dopaminergic SN neurons and could be responsible for psychotic symptoms in DLB patients.
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