Disturbance of serotonergic regulation of hematopoietic stem cells (HSCS CD 34+) and blood mononuclear cells (BMCS) in patients with multiple sclerosis (MS)

Abstract

Background and goals. Serotonin is involved in the mechanisms of regulation of the function of immunocompetent cells through the receptor apparatus. The aim of the study was to evaluate the expression capacity (EC) of BMCs and HSCs under the influence of serotonin - creatine sulfate at a dose of 10−4 M in the “in vitro”test system(TS). Violation of the receptor apparatus of cells serotonin led to a change in their quantitative registration.