Disturbance in glucose metabolism in patients with lichen planus

A S M Zakaria,Ommey Kulsom,Mohammed Saiful Islam Bhuiyan,Abida Sultana,Md Kamal Hossain,Mahmudur Rahman

doi:10.3329/bsmmuj.v9i4.29993

Abstract

<p>The aim of this study was to see the association of lichen planus (n=80) with glucose metabolism disturbance. Classic variety of lichen planus was the most common (76.3%), followed by ashy dermatosis, hypertrophic, oral, actinic and nail lichen planus. The blood glucose level 2 hours after glucose drink was abnormal in 20 cases. HbA<sub>1</sub>c was abnormal in 7 cases. The mean homeostasis model of assessment formulation- insulin resistance index (HOMA-IR) was 2.1 ± 1.6 and it was higher (&gt;4.8) in 12.5% patients. Diabetes mellitus was found in 30 patients. Impaired glucose tolerance was found in 15 cases and high HOMA-IR was found in 10 cases. Total number of cases of abnormal glucose metabolism was found in 55 (68.8%) cases of lichen planus. In conclusion, patients with lichen planus have higher risk of abnormal glucose metabolism specially diabetes mellitus.</p>

Highlights

Lichen planus is an inflammatory keratotic dermatosis of unknown etiology, occurs in 0.51.9% of the population.[1,2] Its classical clinical presentation is characterized by flat-topped, polygonal, papules or plaques of violet color
This cross-sectional study was conducted on 80 patients of lichen planus from November 2013 to
Lichen planus was described more than a century ago, its etiology remains little known

Summary

Introduction

Lichen planus is an inflammatory keratotic dermatosis of unknown etiology, occurs in 0.51.9% of the population.[1,2] Its classical clinical presentation is characterized by flat-topped, polygonal, papules or plaques of violet color. It affects primarily the flexure surface of the wrists, thighs, distal third of lower extremities, abdomen, genitals, nails and oral mucosa. Lichen planus is a pruritic, inflammatory disease of the skin, mucous membrane and hair follicles It occurs throughout the world in all races. It is a common skin disease, comprising more than 0.5% of all dermatological visits. It may be familial in 1-2% of cases.[3]

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