Abstract
Objective: In order to find out the distribution patterns of extracellular matrix (ECM) in hepatocellular carcinoma (HCC) and explore the relationshi between distribution patterns and hepatocellular caricnoma malignancy. Methods: Forty cases of HCC were studied by immunohitochemistry with 5 antibodies of anti-ECM. Results; Four types of distribution patterns were found: 1. continuous peritrabecular or periacinar type; 2. discontinuous peritrabecular or periacinar type; 3. vascular stroma type; 4. membrane and cytoplasmic type. The former 3 types were correlated closely with the growth pattern, cell differntiation and proliferation of tumor. Conclusions: ECM were useful marker for valution of malignant degree in HCC.
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