Abstract
Highest concentrations of vasoactive intestinal peptide (VIP) are found in the rat cerebral cortex and hypothalamic suprachiasmatic nucleus (SCN), located by electronmicroscopic immunocytochemistry in cell bodies, dendrites and nerve terminals. The unchanged level of VIP in the parietal cortex after transection of the corpus callosum supports our former observation that VIP in the cerebral cortex is present in short intrinsic neurons. A similar conclusion can be drawn for the dorsal hippocampus after superior fornix transection. The high VIP level in the SCN is depleted by periventricular transection immediately caudal to the nucleus, indicating that VIP fibers or neuronal inputs necessary for VIP synthesis in the SCN have been lesioned. These neuronal inputs do not seem to be of serotonin origin, since medial forebrain bundle lesion does not alter VIP concentrations in the SCN. Even if a high number of VIP-containing cell bodies are present in the SCN, it does not seem that VIP fibers from this nucleus project to the median eminence directly via a periventricular path or through the retrochiasmatic area.
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