Abstract
The dbl-like GDP/GTP exchange factor, collybistin, binds to the receptor anchoring protein gephyrin and activates the Rho-like GTPase Cdc42. Collybistin was found in two splice variants I and II, both of which share a tandem Dbl homology/pleckstrin homology (DH/PH) domain. In heterologous expression systems, collybistin II induces the formation of submembraneous gephyrin aggregates and therefore has been implicated in inhibitory synapse formation. Expression of collybistin is restricted to neuronal tissues and is predominantly found in brain. Here, we investigated the spatio-temporal distribution of collybistin transcripts in the embryonic mouse brain and compared it to gephyrin and glycine receptor mRNA patterns. Our data show that collybistin expression is upregulated when neurons become postmitotic and start to differentiate.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
