Abstract
Introduction Type1 diabetes mellitus (T1DM) is a chronic autoimmune disease result in destruction of pancreatic beta cells lead to the clinical form of the disease (1). Unfortunately a recent study reported increasing in the incidence of the disease by 2-5% globally (2). However the prevalen
Highlights
Type[1] diabetes mellitus (T1DM) is a chronic autoimmune disease result in destruction of pancreatic beta cells lead to the clinical form of the disease1. a recent study reported increasing in the incidence of the disease by 2-5% globally2. the prevalence in Saudi Arabia is higher in compare to other communities[3]
Perhaps the autoimmune thyroid diseases are the commonest[4], estimated about 40% in cohort study in Germany and Austria[5]. Both autoimmune thyroiditis and type 1 DM are organ specific autoimmune disease mediated by T cells and probably they have same pathogenesis, their accompanied occurrence may explained by sharing some susceptibility genes[6]
The plasma concentrations of autoantibodies were significantly increased in diabetic patients in compared to controls P value d” 0.03
Summary
Type[1] diabetes mellitus (T1DM) is a chronic autoimmune disease result in destruction of pancreatic beta cells lead to the clinical form of the disease[1]. a recent study reported increasing in the incidence of the disease by 2-5% globally[2]. the prevalence in Saudi Arabia is higher in compare to other communities[3]. the disease known to be associated with multiple autoimmune diseasesHASSAN et al, Biomed. & Pharmacol. Type[1] diabetes mellitus (T1DM) is a chronic autoimmune disease result in destruction of pancreatic beta cells lead to the clinical form of the disease[1]. a recent study reported increasing in the incidence of the disease by 2-5% globally[2]. the prevalence in Saudi Arabia is higher in compare to other communities[3]. Perhaps the autoimmune thyroid diseases are the commonest[4], estimated about 40% in cohort study in Germany and Austria[5]. Both autoimmune thyroiditis and type 1 DM are organ specific autoimmune disease mediated by T cells and probably they have same pathogenesis, their accompanied occurrence may explained by sharing some susceptibility genes[6]. The higher prevalence of thyroid autoantibodies as well as abnormal thyroid profiles were detected among type 1 DM children and adolescence including their first-degree relatives[7,8]
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