Distribution of the Val108/158 Met Polymorphism of COMT Gene in the Khasi, Garo, Jaintia Populations of Northeast India

Kripamoy Aguan

doi:10.19080/oajnn.2017.03.555621

Abstract

Distribution of the Val108/158 Met Polymorphism of COMT Gene in the Khasi, Garo, Jaintia Populations of Northeast India

Highlights

Catechol-O-methyltransferase (COMT) is one of the major mammalian enzymes involved in the metabolic degradation of catecholamine
The enzyme catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to a hydroxyl group on a catechol nucleus, thereby it inactivates catecholamine and catechol drugs [1,2,3]
The most common variation of the COMT gene is the valine to methionine changes at amino acid position 108 in S-COMT and valine to methionine changes at amino acid position 158 in MB-COMT

Summary

Introduction

Catechol-O-methyltransferase (COMT) is one of the major mammalian enzymes involved in the metabolic degradation of catecholamine. COMT is important for the efficient functioning of prefrontal cortex (PFC) of the brain which organizes and coordinates information from other parts of the brain. This region is involved in personality, planning, and inhibition of behaviors, abstract thinking, emotion, and working memory [4,5]. Several studies have confirmed that either too little or too much of dopamine in PFC impairs the working and recognition memory [6,7,8,9,10] Since it is involved in various aspects of cognition, COMT has been studied in details for its genetic variation.

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Discussion

Conclusion