Abstract
BackgroundSerum amyloid A (SAA) plays a critical role in acute or chronic and is used in clinical laboratories as an indicator of inflammation. The elevated SAA is closely related to inflammation‐mediated diseases, such as liver diseases, autoimmune diseases, metabolism‐related diseases, amyloidosis, and tumors. However, there is no unified population reference interval for SAA. This study aimed to investigate the distribution of SAA in healthy Chinese adults 20‐79 years of age and to establish its population reference interval.MethodsA total of 2365 healthy subjects met the requirements of this study. The levels of SAA were detected using an AU5821 automatic biochemical analyzer and its original reagents. According to the recommended methods of CLSI C28‐A3 and WS/T 402‐2012, the population reference interval of SAA was established using the unilateral 95th percentile (P95), and the 90% confidence interval of upper limits was calculated.ResultsThe distributions of SAA levels were not significantly different between sexes (P> .05) and also did not differ by age (P> .05). Therefore, the population reference interval for SAA was established as an upper limit of 11.0 mg/L (90% confidence interval: 9.3‐12.3 mg/L) by using the method of latex immunoturbidimetry.ConclusionsSerum amyloid A is closely related to the occurrence and progression of various diseases. The preliminary establishment of a population reference interval for SAA can fully exert its potential clinical value.
Highlights
Serum amyloid A (SAA) plays n critical role in acute or chronic and is used in clinical laboratories as an indicator of inflammation.[1]
Serum amyloid A is an important acute‐phase reactive protein mainly produced by liver, which can eliminate pathogens in the body and fa‐ cilitate disease recovery.[18,19]
This study combined the regional characteristics of population distribution and eating habits in coastal cities, established strict normative inclusion and exclusion criteria for reference individuals, and confirmed 2365 healthy people with physical examinations as the research cohort
Summary
Serum amyloid A (SAA) plays n critical role in acute or chronic and is used in clinical laboratories as an indicator of inflammation.[1]. Because the reference interval is susceptible to methodological differences, population characteristics and geographical differences, the refer‐ ence interval provided by the reagent manufacturer has limitations, so a laboratory self‐built reference interval is import‐ ant.[12,13] so far there have been a few reports about the establishment of SAA reference intervals in humans.[14,15] the present study was conducted through recruitment, sampling, and measurement. We collected data of healthy sub‐ jects, conducted preliminary analyses, and established the reference interval of SAA by using latex‐enhanced immunoturbidimetry for healthy adults in China. These reference values can be used for the clinical application of SAA‐related diseases
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