Abstract
Abstract The number of heteropolysaccharide units of prothrombin has been reinvestigated and their distribution upon activation has been determined. The results of this study suggest that prothrombin contains three heteropolysaccharide units, and that upon activation two units are present in the intermediate 3 portion of the molecule and one unit is present in the intermediate 1 portion. Subsequent activation of intermediate 1 yields intermediate 4, which is devoid of carbohydrate and intermediate 2, the immediate thrombin precursor, which contains one heteropolysaccharide unit. Cleavage of intermediate 2 to yield α-thrombin is a conservative process with respect to carbohydrate, while the conversion of α-thrombin to β-thrombin results in the loss of a carbohydrate containing component X.
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