Distribution of progesterone to the uterus and associated vasculature of cattle.

Abstract

Multiparous dairy cows were sampled to study the concentrations of progesterone in tissue of the uterus and associated vasculature and to determine whether progesterone was delivered to the uterus locally. In study 1, progesterone was greater (p less than or equal to 0.05) in the first venous branch draining the cranial portion of the uterine cornu adjacent to the vary with a corpus luteum than in jugular blood or in the same vein draining the opposite uterine cornu on day 11 postestrus. Concentrations of progesterone were also greater (p less than or equal to 0.05) in the cranial than in the caudal half of the uterine cornu adjacent to the luteal-bearing ovary or in the cranial and caudal halves of the opposite uterine cornu. Concentrations of progesterone were also greater (p less than or equal to 0.05) in the uterine or ovarian arterial tissue adjacent to the ovary with the corpus luteum than in those same vessels on the contralateral side. In a second study, progesterone at 0 h on day 11 postestrus was greater (p less than or equal to 0.05) in the first venous branch draining the cranial portion of the uterine horn adjacent to the luteal-bearing ovary than in jugular blood, the same vein in the contralateral uterine cornu or in the same uterine vein 48 h after ligation and resection of the oviductal vein adjacent to the ovary with the corpus luteum. It is concluded that progesterone is delivered locally to the uterus and associated vasculature and the route of local delivery appears to be via the oviductal vein.