Abstract
The distribution of various polychlorinated dibenzo- p-dioxins and dibenzofurans (PCDDs and PCDFs) was measured in rat tissues following various routes of administration: subcutaneous or intraperitoneal (vehicle: mixture of toluene and DMSO). Subsequent to intraperitoneal injection the deposit within the liver was found to be almost identical with that found after subcutaneous injection. In contrast, much higher concentrations of the congeners were found in (abdominal) adipose tissue subsequent to an intraperitoneal injection. The extent of subcutaneous absorption was also measured using an oil-containing vehicle. Speed of absorption was found to be lower when compared with the vehicle without oil. This led to considerably lower concentrations in liver and adipose tissue for most PCDD/PCDF-congeners.
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